The 5-HTR: A Widely Studied Neurotransmitter Receptor (P12998)

Target Name: 5-Hydroxytryptamine Receptor

NCBI ID: P12998

5-Hydroxytryptamine Receptor

Other Name(s): Serotonin receptor | 5-HT | 5-HTR

The 5-HTR: A Widely Studied Neurotransmitter Receptor

The 5-hydroxytryptamine receptor (5-HTR), also known as the serotonin receptor, is a family of G protein-coupled receptors that play a crucial role in various physiological processes in the body. The 5-HTR is one of the most widely studied receptors in the neurotransmitter system, and its function in neural circuits has been extensively investigated.

The 5-HTR is a transmembrane receptor that is located throughout the brain and body. It is involved in the regulation of various physiological processes, including mood regulation, anxiety, pain perception, and neurotransmitter release. The 5-HTR is a G protein-coupled receptor, which means that it is composed of a protein called G protein, which is further composed of a伪,尾,纬 subunit.

The 5-HTR is classified into two main subtypes, which are non-specified subtype and serotonin subtype. The non-specified subtype is also known as GPR55 or CRM1, and it is expressed in the brain, skin, and other tissues. The serotonin subtype, on the other hand, is expressed in the brain and is involved in the regulation of mood, anxiety, and pain perception.

The 5-HTR is involved in the regulation of various neurotransmitters, including serotonin, dopamine, and norepinephrine. It is well established that the 5-HTR plays a crucial role in the regulation of mood and anxiety. Studies have shown that changes in the levels of serotonin in the brain can have a significant impact on mood and anxiety.

One of the well-known functions of the 5-HTR is its role in pain perception. Studies have shown that activation of the 5-HTR can lead to the release of endogenous opioids, which can reduce pain perception. Additionally, the 5-HTR is involved in the regulation of pain modulation, and changes in its function have been linked to the development of chronic pain conditions.

The 5-HTR is also involved in the regulation of mood regulation. Studies have shown that changes in the levels of serotonin in the brain can have a significant impact on mood. For example, low levels of serotonin have been linked to feelings of sadness and anxiety, while high levels of serotonin have been linked to feelings of happiness and tranquility.

Another well-known function of the 5-HTR is its role in neurotransmitter release. The 5-HTR is involved in the regulation of the release of various neurotransmitters, including serotonin, dopamine, and norepinephrine. Studies have shown that changes in the levels of these neurotransmitters can have a significant impact on mood and behavior.

In addition to its role in neurotransmitter regulation, the 5-HTR is also involved in the regulation of ion channels in the brain. Studies have shown that changes in the levels of ion channels in the brain can have a significant impact on the function of the 5-HTR.

Overall, the 5-HTR is a G protein-coupled receptor that is involved in a wide range of physiological processes in the body. Its function in neural circuits has been extensively investigated, and its role in the regulation of mood, anxiety, and pain perception is well established. The 5-HTR is a potential drug target and a biomarker for various psychiatric and neurological disorders, including depression, anxiety, and chronic pain.

Protein Name: 5-Hydroxytryptamine Receptor (nonspecified Subtype)

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